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Target intelligence / Profile preview
Guanylate cyclase soluble subunit beta-1 (sGCβ1)
- Target
- sGCβ1
- Molecular classification
- Enzyme, Receptor
01
Overview
Guanylate cyclase soluble subunit beta-1 (sGCβ1) is a subunit of the soluble guanylate cyclase (sGC) enzyme, which is a heterodimer composed of an alpha and a beta subunit. This enzyme catalyzes the conversion of GTP to cGMP, an important second messenger involved in various physiological processes, notably vascular tone regulation. It serves as the main receptor for nitric oxide (NO).
- Other names
- GC-SB3GUCSB3GUCY1B3GC-S-beta-1GUCB3
02
Mechanism of action
Stimulation or activation of soluble guanylate cyclase, leading to increased cGMP production.
03
Biological functions
Signal transductionVasodilationPlatelet aggregation inhibitionCardiac function regulationNeurotransmission modulation
04
Disease associations
Cardiovascular diseaseNemaline Myopathy type 7Bartter Syndrome type II
05
Safety considerations
Potential for hypotensionLimited efficacy in certain patient populations
06
Interacting drugs
Runcaciguat
1 more in the full profile.
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