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Guanylyl Cyclase A Receptor (GC-A)
- Target
- GC-A
- Molecular classification
- Receptor, Enzyme, Guanylyl Cyclase, Transmembrane receptor
01
Overview
The Guanylyl Cyclase A receptor (GC-A), also known as natriuretic peptide receptor-A (NPRA or NPR1), is a transmembrane receptor and enzyme that primarily binds atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Activation of GC-A leads to the production of cGMP, a second messenger involved in regulating blood pressure, blood volume, cardiac growth, and energy balance. It is highly expressed in the heart, vascular smooth muscle, and kidneys.
- Other names
- Natriuretic Peptide Receptor ANPRANPR1Guanylate Cyclase AGUCY2A
02
Mechanism of action
ANP/BNP binding activates intracellular guanylyl cyclase domain, leading to cGMP production and downstream signaling.
03
Biological functions
Signal transductionVasodilationNatriuresisDiuresisRegulation of blood pressureRegulation of fluid volumeCardiac remodelingcGMP production
04
Disease associations
Cardiovascular diseaseHypertensionHeart failureKidney disease
05
Safety considerations
HypotensionElectrolyte imbalance
06
Interacting drugs
ANP
1 more in the full profile.
07
Biomarkers
ANP levelsBNP levels
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