GUSB pseudogene 1 (GUSBP1)

GUSBP1, or GUSB pseudogene 1, encodes a putative inactive beta-glucuronidase-like protein and is classified as a pseudogene in the human genome[5][3]. Pseudogenes are generally inactive gene sequences that resemble functional genes but typically lack the capacity to encode functional proteins due to mutations or deletions. GUSBP1 shares homology with the functional GUSB gene, which encodes the lysosomal enzyme beta-glucuronidase, but GUSBP1 itself is not an active enzyme and has no known biological or pathological function[3][5][7]. There is no evidence that GUSBP1 acts as a therapeutic target, nor is it linked to known drug interactions, biomarker roles, or clinical safety concerns. Its designation as a pseudogene means it does not participate in cellular pathways regulated by enzymes, receptors, or similar druggable entities. GUSBP1 is sometimes referred to by alternative names such as "Putative inactive beta-glucuronidase-like protein SMA3" and "SMA3"[5][3]. Because it is a pseudogene and not an active gene product, it is not considered a therapeutic target and its inclusion in drug target lists would be incorrect[5][3].

Other names

Putative inactive beta-glucuronidase-like protein SMA3SMA3GUSBP1