GUSB pseudogene 18 (GUSBP18)

GUSBP18 (GUSB pseudogene 18) is classified as a transcribed pseudogene in the human genome, meaning that while it is a DNA sequence related to the functional GUSB (Glucuronidase beta) gene, it does not encode a functional protein and has no known biological or disease roles. It is not a recognized drug target, and current sources indicate it does not contribute to disease or therapeutic mechanisms. Ensembl records GUSBP18 as a transcribed pseudogene (ENSG00000215158), with no association with disease, therapy, or protein function. Many pseudogenes for the true GUSB gene exist, but only the canonical GUSB gene provides a functional enzyme with defined biological and pathological roles; GUSBP18 is not one of these. Pseudogenes like GUSBP18 arise during genome evolution and are often considered non-functional, though rare exceptions of regulatory function exist. There is no evidence that GUSBP18 has such roles. In summary, GUSB pseudogene 18 (GUSBP18) is not a therapeutic target, is not involved in any known normal or disease biology, and should not be confused with the functional lysosomal enzyme beta-glucuronidase (GUSB).

Other names

GUSBP18