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Gut Epithelial Barrier Integrity Markers (N/A)
- Target
- N/A
- Molecular classification
- Amino acid, Cytoplasmic protein, Tight-junction modulator, LPS-binding protein, Tight-junction proteins, Ca-binding protein
01
Overview
Gut epithelial barrier integrity markers are molecules or proteins used to assess the health and function of the intestinal epithelial barrier. These markers include citrulline, I-FABP, zonulin, LBP, claudins, and calprotectin. Alterations in these biomarkers can provide insights into early detection of mucosal injury, monitoring disease progression/remission, and evaluating response to therapy targeting mucosal healing. Elevated levels often precede clinical symptoms or histological changes.
02
Mechanism of action
N/A
03
Biological functions
Enterocyte mass maintenanceEpithelial cell integrityTight-junction regulationMicrobial translocation detectionJunctional complex formationInflammation detection
04
Disease associations
Mucosal atrophyIntestinal ischemiaIntestinal permeabilitySystemic inflammationCrohn's DiseaseGastrointestinal inflammationInflammatory Bowel DiseaseCeliac Disease
05
Safety considerations
Specificity issues with some zonulin ELISA kitsCalprotectin elevation can be caused by various inflammatory conditions
06
Biomarkers
CitrullineI-FABPZonulinLBPClaudinsCalprotectin
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