Gut microbiome–host interface

The gut microbiome–host interface refers to the dynamic and multifaceted interactions between the community of microorganisms (including bacteria, viruses, fungi, and archaea) inhabiting the human gastrointestinal tract and the host's immune, metabolic, and neuroendocrine systems[1][5]. This interface is critical to maintaining gut barrier integrity, immune tolerance, nutrient absorption, and protection against pathogens. Disruption of this interface (dysbiosis) is implicated in a range of diseases, including inflammatory, metabolic, autoimmune, and neurological disorders[3][4]. The gut microbiome and its interface with the host are not a discrete molecular target or receptor, but rather represent an ecosystem and a physiological boundary encompassing physical barriers (e.g., mucosal layers), cellular components (e.g., immune cells), and molecular mediators (e.g., IgA, microbial metabolites)[1][2][3][6][7]. Note: - This entry is marked is_incorrect: true because "Gut microbiome / Host-microbiome interface" is not a discrete molecular target, receptor, enzyme, or single protein, but rather an ecosystem-level concept spanning multiple cell types, molecular pathways, and systems. - There is no canonical single molecule, abbreviation, or gene/protein that corresponds to this entity. Structured drug-target databases typically do not treat it as a molecular target but recognize it as a context for host–microbial interactions and potential intervention[3][5][6].

Other names

Gut microbiomeHost–microbiome interfaceHuman gut microbiomeIntestinal microbiome

Modulation of microbial composition (e.g., by antibiotics or probiotics); Alteration of microbial-derived metabolites (e.g., short-chain fatty acids); Modulation of immune signaling pathways