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Target intelligence / Profile preview
Gut Microbiome Composition Restoration
- Molecular classification
- Ecosystem-level intervention, Microbiota-based therapy
01
Overview
Gut microbiome composition restoration refers to therapeutic strategies aimed at re-establishing a healthy, diverse, and balanced community of microorganisms in the human gastrointestinal tract. This target is not a single molecule or receptor but rather an ecosystem-level intervention focused on correcting dysbiosis—an imbalance or loss of beneficial gut bacteria—which is associated with various diseases.
02
Mechanism of action
Re-establishment of a healthy, diverse, and balanced community of microorganisms in the human gastrointestinal tract.
03
Biological functions
Metabolic homeostasisImmune system regulationProtection against pathogenic infectionsProduction of key metabolites (e.g., short-chain fatty acids)Restoration of microbial diversity
04
Disease associations
Recurrent Clostridioides difficile infection (CDI)Metabolic disordersImmune dysfunctionMetabolic syndromeInflammatory bowel diseasesNeuropsychiatric conditions
05
Safety considerations
Risk of infection transmission via FMTPotential for unintended ecological consequencesVariability in donor stool composition (FMT)Long-term effects of altered gut microbiome composition are not fully understood
06
Interacting drugs
Fecal Microbiota Transplantation (FMT)
5 more in the full profile.
07
Biomarkers
Changes in gut microbial diversityLevels of Faecalibacterium prausnitziiLevels of Bifidobacterium spp.Levels of Lactobacillus spp.Levels of Roseburia spp.Levels of Eubacterium rectale
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