Gut microbiota–host epithelial surface interaction (null)

The **gut microbiota–host epithelial surface interaction** encompasses the intricate and bidirectional relationship between the vast community of microorganisms residing in the gut (including bacteria, archaea, viruses, and fungi) and the epithelial lining of the gastrointestinal tract. This interaction maintains homeostasis by: - Supporting barrier integrity through regulation of tight junctions, mucin production, and antimicrobial peptide secretion - Modulating immune responses and inflammation - Influencing host metabolism and nutrient absorption via microbial metabolites (e.g., short-chain fatty acids, bile acids, indole derivatives) - Protecting against pathogen invasion Disruption of this relationship (dysbiosis or barrier dysfunction) is linked to diseases such as inflammatory bowel disease, colorectal cancer, infections, and metabolic disorders. Current research focuses on deciphering the molecular mechanisms underlying this crosstalk and developing strategies (such as probiotics, dietary interventions, and microbiome-modifying drugs) to restore or enhance beneficial host–microbe interactions[1][2][3][4][5].

Other names

gut microbiota–epithelium interactionmicrobiota–epithelial cell crosstalkmicrobiota–host interface

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