Gut Microbiota and Host Lipogenic Gene Expression

The term 'Gut Microbiota and Host Lipogenic Gene Expression' refers to the regulatory effects exerted by the gut microbial community on the host's genes responsible for the synthesis of fatty acids (lipogenesis). Research has shown that gut microbiota can modify host metabolic pathways by altering the expression of key transcriptional regulators and enzymes involved in hepatic and intestinal lipogenesis, such as SREBP-1c (sterol regulatory element binding protein-1c), fatty acid synthase (FASN), ChREBP, and others. These effects can be influenced by diet, the presence or absence of specific microbial taxa, and microbial metabolites, leading to significant impacts on metabolic health, obesity, and fatty liver disease. The manipulation of the gut microbiome is being explored as a possible avenue for modulating host metabolism and treating metabolic diseases. However, this entry does not correspond to a defined molecular target such as a receptor or enzyme and should be described as a biological pathway or process, not as a canonical drug target.[1][2][4][6]

Other names

Gut microbiome regulation of host lipid metabolismGut microbiota–lipogenic gene expression axisMicrobiota-induced lipogenic gene regulation