Gut microbiota composition and metabolites (null)

Gut microbiota composition and metabolites describe the diverse population of microorganisms residing in the gastrointestinal tract and the wide array of molecules (e.g. short-chain fatty acids, bile acids, phenolic compounds) they produce through dietary fermentation, host compound transformation, and direct biosynthesis. These microbial metabolites have profound effects on host health, affecting metabolic processes, immune regulation, neurobiology, and disease development. Therapeutic strategies increasingly focus on modulating gut microbiota composition or targeting specific microbial metabolites, as growing evidence connects these with insulin resistance, cancer, neurodegenerative diseases, cardiovascular pathologies, and other systemic conditions.

Other names

Intestinal microbiota and metabolitesgut flora metabolitesmicrobial metabolitesgut microbial metabolites

Modulation of metabolic pathways (e.g. increased production of beneficial SCFAs); Restoration of microbial community balance (reduction of dysbiosis); Inhibition or activation of host receptors, e.g. GPCRs (via microbial metabolites); Alteration of host gene transcription (via HDAC inhibition)