Gut microbiota dysbiosis restoration

Gut microbiota dysbiosis restoration is a therapeutic strategy aimed at reestablishing the healthy balance, diversity, and function of the gastrointestinal microbial community when disrupted. Restoration strategies include the use of probiotics, prebiotics, synbiotics, dietary modifications, FMT, and emerging biotherapeutics. These interventions are designed to overcome a loss of beneficial microbes, diminishing diversity, and overgrowth of potentially pathogenic species that characterize dysbiosis. Restoration is not an action at a single molecular target but is an ecological, compositional, and functional rebalancing of a complex microbial ecosystem, often with impacts on immune regulation, metabolic function, and systemic disease processes[1][2][3][6]. In summary, “gut microbiota dysbiosis restoration” should not be regarded as a molecular drug target but as a multifaceted therapeutic approach, with its interventions interacting with numerous known (and sometimes unknown) molecular and cellular pathways.

Other names

microbiota restorationcorrection of gut dysbiosisrestoration of gut microbial balance

Restoration of microbial diversity by introducing beneficial microorganisms (probiotics, FMT); Promotion of beneficial microbial growth through specific dietary components (prebiotics); Competition with or inhibition of pathogenic microbes; Modulation of immune system by microbial metabolites (e.g., short-chain fatty acids); Modulation of intestinal barrier function