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Gut Microbiota Restoration
- Molecular classification
- Microbial community, Ecosystem
01
Overview
Gut microbiota restoration refers to therapeutic strategies aimed at re-establishing a healthy, diverse, and balanced community of microorganisms in the gastrointestinal tract. This is typically pursued after disruption (dysbiosis) caused by antibiotics, infections (notably recurrent Clostridioides difficile infection), or other factors that negatively impact gut microbial diversity and function. Approaches include fecal microbiota transplantation (FMT), defined bacterial consortia, probiotics, prebiotics, and synbiotics.
- Other names
- Gut microbiome restorationFecal Microbiota Transplantation (FMT)Defined Bacterial ConsortiaProbioticsPrebioticsSynbiotics
02
Mechanism of action
Repopulates depleted/dysbiotic gut flora with beneficial microbes
03
Biological functions
Digestion and nutrient absorptionImmune system modulationProtection against pathogenic organismsMetabolic regulationMicrobial community homeostasis
04
Disease associations
Recurrent Clostridioides difficile infectionMetabolic disordersImmune dysregulationInflammatory bowel diseaseIrritable bowel syndromeColonization by antibiotic-resistant bacteria
05
Safety considerations
Transmission of infectious agents with FMTUnpredictable long-term effects of transferred microbesVariable efficacy of probioticsPotential for adverse reactions to specific bacterial strains
06
Interacting drugs
Antibiotics
5 more in the full profile.
07
Biomarkers
Increased microbial diversity (alpha-diversity)Re-establishment/presence of key commensal taxa (e.g., Bacteroides spp., Faecalibacterium prausnitzii)Reduction in abundance/resistome load of pathogenic/antibiotic-resistant organisms
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