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Gut Mucosal Surface (N/A)
- Target
- N/A
- Molecular classification
- Epithelium, Connective Tissue, Immune Tissue, Mucus Layer
01
Overview
The gut mucosal surface is the innermost lining of the gastrointestinal (GI) tract. It is a complex and dynamic interface that plays a critical role in digestion, nutrient absorption, immune defense, and maintaining gut homeostasis. It comprises epithelial cells, lamina propria, muscularis mucosae, mucus layer, immune elements, and microbiota, all working together to provide a selective barrier, facilitate nutrient uptake, and protect the body from harmful substances and pathogens. While not a single druggable target, its integrity is essential for overall health, and various diseases can arise from its dysfunction.
- Other names
- GI mucosaIntestinal mucosaGut epitheliumIntestinal epitheliumIntestinal barrierGut barrier
02
Mechanism of action
N/A
03
Biological functions
DigestionNutrient absorptionImmune defenseBarrier functionSecretionProtection
04
Disease associations
Inflammatory Bowel Disease (IBD)Irritable Bowel Syndrome (IBS)Colorectal Cancer (CRC)InfectionMalabsorptionFood Allergies
05
Safety considerations
Increased intestinal permeabilityDysbiosisInflammationUlcerationBleedingInfection
06
Interacting drugs
Non-steroidal anti-inflammatory drugs (NSAIDs)
5 more in the full profile.
07
Biomarkers
ZonulinFecal calprotectinLactulose/mannitol ratioIntestinal permeability markersSpecific IgA antibodies
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