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Target intelligence / Profile preview
Gypsy retrotransposon integrase 1 (GIN1)
- Target
- GIN1
- Molecular classification
- Other (domesticated transposon-derived gene, integrase-like protein; related to LTR retrotransposons and retroviral integrases)
01
Overview
Gypsy retrotransposon integrase 1 (GIN1) is a protein-coding gene derived by molecular domestication from ancestral Gypsy/Ty3/Gypsy LTR retrotransposon integrases and is present in mammals, birds, and reptiles[2][3]. GIN1 contains a conserved HHCC zinc finger domain, suggesting possible nucleic acid binding capabilities, and shares some key residues with retrotransposon integrases, though its integrase catalytic activity in vertebrates is not established[2][3]. Its biological role in vertebrates remains unknown, and there are no current data linking GIN1 to specific diseases or therapeutic applications; it is not a recognized therapeutic target[2][3].
- Other names
- Gypsy retrotransposon integrase-like protein 1TGIN1ZH2C2GIN-1FLJ20125Ty3/Gypsy integrase 1Zinc finger H2C2 domain-containing protein
02
Biological functions
Unknownsuggested to involve nucleic acid binding, possibly influenced by the presence of a zinc finger domain
03
Disease associations
Other (no established disease linkage; biological function remains unknown)
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