GZMH and GZMB antisense RNA 1 (GZMH-AS1)

GZMH and GZMB antisense RNA 1 (GZMH-AS1, also referred to as AL136018.1) denotes a long non-coding natural antisense transcript (NAT) at the locus overlapping the granzyme H (GZMH) and granzyme B (GZMB) genes, which encode proteases involved in cytotoxic lymphocyte-mediated apoptosis. Antisense RNAs such as GZMH-AS1 can theoretically regulate their associated sense mRNAs post-transcriptionally or transcriptionally, often via mechanisms involving chromatin modification, RNA duplex formation, or interference with splicing[2][3]. However, there is no direct experimental evidence or published data specifically characterizing the biological function, disease involvement, therapeutic relevance, or drug interactions for GZMH-AS1. Its presence may be annotated in certain transcriptome databases but is not currently considered a canonical receptor, enzyme, transporter, or drug target. The absence of published functional or disease association data means it is not classified as a therapeutic target. If you need structured data for automated systems, the record for GZMH-AS1 should be flagged as incomplete and potentially misleading for target-based research, pending further biochemical or cellular characterization.

Other names

AL136018.1GZMH-AS1