H type 1 antigen (H1)

H type 1 glycan is a trisaccharide structure (Fucα1-2Galβ1-3GlcNAc) that serves as a critical cell surface antigen and a precursor for the ABO blood group system (Marionneau et al., 2001, Glycobiology). Unlike H type 2, which is primarily found on erythrocytes, H type 1 is predominantly expressed on epithelial cells and in bodily secretions, regulated by the FUT2 (secretor) gene (Lindesmith et al., 2003, Nature Medicine). It plays a significant role in host-pathogen interactions, acting as a primary attachment receptor for various enteric pathogens, including noroviruses and Helicobacter pylori (Tan & Jiang, 2005, Trends in Microbiology). Individuals who lack this glycan (non-secretors) often exhibit resistance to certain viral infections but may have increased susceptibility to others, such as Crohn's disease (McGovern et al., 2010, Nature Genetics). Therapeutic strategies targeting H type 1 involve the use of glycan mimetics or decoy molecules, such as 2'-fucosyllactose, to block pathogen adhesion and prevent infection (Weichert et al., 2016, Journal of Virology).

Other names

H type 1 glycanFucα1-2Galβ1-3GlcNAcBlood group H type 1Secretor antigenH-1 antigen

Competitive inhibition of pathogen binding to host cell surface glycans by acting as a decoy receptor or blocking the binding site.