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Target intelligence / Profile preview
H1 Histamine Receptor (H1R)
- Target
- H1R
- Molecular classification
- G protein-coupled receptor, GPCR
01
Overview
The H1 histamine receptor (H1R) is a member of the rhodopsin-like family of G-protein-coupled receptors (GPCRs). It is activated by the endogenous biogenic amine histamine and plays a central role in mediating allergic responses, inflammation, and various physiological processes in both the peripheral and central nervous systems.
- Other names
- HRH1
02
Mechanism of action
Receptor antagonism
03
Biological functions
Signal transductionInflammationSmooth muscle contractionVascular permeability regulationNeurotransmissionNociception
04
Disease associations
Allergic responseInflammationNeurological disordersInfection
05
Safety considerations
Drowsiness (first-generation antihistamines)Potential for incomplete control of conditions like acute pruritus or atopic dermatitis
06
Interacting drugs
Antihistamines
1 more in the full profile.
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