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Target intelligence / Profile preview
H19 Gene Promoter-Driven Diphtheria Toxin A Expression (DTA-H19)
- Target
- DTA-H19
- Molecular classification
- Gene therapy, Promoter sequence, Diphtheria toxin A
01
Overview
This gene therapy strategy uses the H19 gene promoter to drive expression of the diphtheria toxin A (DTA) subunit. H19 is highly expressed in many tumors but largely silent in normal adult tissues, making its promoter suitable for tumor-specific expression of DTA to induce selective cancer cell death. The therapeutic construct BC-819/DTA-H19 contains regulatory sequences from the human H19 promoter driving expression of diphtheria toxin A.
- Other names
- BC-819
02
Mechanism of action
Tumor-specific expression of diphtheria toxin A (DTA) driven by the H19 promoter, leading to inhibition of protein synthesis and apoptosis in cancer cells.
03
Biological functions
Tumor-selective cell deathInhibition of protein synthesisGene expression regulation
04
Disease associations
Cancer
05
Safety considerations
Off-target toxicityImmunogenicityPotential for insertional mutagenesis
06
Interacting drugs
BC-819
07
Biomarkers
H19 expression level
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