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Target intelligence / Profile preview
H19 long non-coding RNA promoter-driven expression of diphtheria toxin A chain (None)
- Target
- None
- Molecular classification
- Gene Therapy Construct, Non-coding RNA promoter, Cytotoxin
01
Overview
The "H19 long non-coding RNA promoter-driven expression of diphtheria toxin A chain" system leverages tumor-specific transcriptional activity at the lncRNA-H19 locus to selectively induce lethal toxicity through intracellular production of diphtheria toxin's catalytic domain—a strategy designed for precise targeting and elimination of malignant cells that aberrantly express this developmental regulator.
02
Mechanism of action
Tumor-selective expression of Diphtheria Toxin A chain, leading to ADP-ribosylation of eEF-2 and inhibition of protein synthesis.
03
Biological functions
Cell deathTumor ablationProtein synthesis inhibition
04
Disease associations
Cancer
05
Safety considerations
Off-target toxicityImmunogenicityInsertional mutagenesis
06
Biomarkers
H19 expression levels in tumor tissueH19 promoter activity
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