H2.0-like homeobox protein (HLX)

H2.0-like homeobox protein (HLX) is a sequence-specific DNA-binding transcription factor encoded by the HLX gene in humans[1][3][7]. It belongs to the homeobox family and is critical in regulating embryogenesis, particularly the development and expansion of visceral organs such as the liver and gut, as well as hematopoiesis[1][3][7]. HLX is required for TBX21/T-bet–dependent maturation and maintenance of Th1 cells, implicating it in immune response regulation[3][4]. Diseases associated with HLX include congenital malformations like diaphragmatic hernia-short bowel-asplenia syndrome and Coffin-Siris syndrome[3]. There is no evidence for approved therapeutic drugs targeting HLX directly, nor are there established mechanisms of pharmacologic action, biomarkers, or specific safety concerns publicly documented in current databases. HLX remains a notable factor in developmental biology and disease pathology due to its regulatory role in cellular differentiation and organogenesis[1][3][4][7].

Other names

HLXHLX1HB24Homeobox protein HB24Homeobox protein HLX1H2.0 like homeoboxH2.0-like homeo box-1H2.0-like homeobox 1