Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
H2A clustered histone 4 (H2AC4)
- Target
- H2AC4
- Molecular classification
- Histone, Core histone protein, Chromatin component, Nucleosome structural protein
01
Overview
H2A clustered histone 4 (H2AC4) is a core histone protein in eukaryotes responsible for forming the nucleosome structure of chromatin by helping package DNA. It is one member of a large family of H2A histone variants that play a central structural role in chromatin by forming an octameric nucleosome core with other histones (H2B, H3, H4)[1][4]. H2A clustered histone 4 is encoded by replication-dependent histone genes clustered in the genome and possesses subtle sequence variations, especially in the C-terminus, that influence how DNA is packed and accessed. While not a typical drug target or receptor, alterations in expression or modification of H2A histones can be linked to changes in chromatin architecture and gene regulation, and somatic mutations or aberrant post-translational modifications may contribute to cancer epigenetics and other chromatin-related disorders[1][3][4].
- Other names
- Histone H2A type 1-B/EH2AFMHIST1H2ABH2AFAHIST1H2AEH2A/mHistone H2A.2Histone H2A/aH2AC8histone H2A type 1-B/EH2A histone family, member Mhistone 1, H2abhistone H2A/mhistone cluster 1 H2A family member bH2A clustered histone 4
02
Biological functions
Chromatin packagingDNA organizationRegulation of nucleosome stability and dynamicsSupport for DNA replication and transcriptional regulation
03
Disease associations
Other (not directly a disease driver, but misregulation is associated with cancer and genome instability[1])
Beyond the preview
Go deeper on H2A clustered histone 4 (H2AC4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on H2A clustered histone 4 (H2AC4).