H2A clustered histone 9, pseudogene (H2AC9P)

H2A clustered histone 9, pseudogene (H2AC9P), also known as HIST1H2APS3, is a member of the histone H2A gene family found in cluster 1 on human chromosome 1[5]. Unlike protein-coding histone genes, H2AC9P contains mutations and alterations in coding and flanking regions that preclude its transcription into a functional histone protein[1][3]. These alterations may include frame-shift mutations, deletions, substitutions, and loss of consensus transcriptional sequences, which make it a non-functional pseudogene rather than a true structural or regulatory protein[1][3]. Thus, H2AC9P does not contribute to nucleosome or chromatin structure and does not act as a molecular target for therapeutic intervention. Key points: - H2AC9P is classified specifically as a pseudogene and not as a protein-coding or functional histone gene[5]. - It is not considered a therapeutic target such as receptor, enzyme, transporter, or transcription factor—there is no current evidence of functional protein expression or drug interaction for this gene. - Listing this gene as a drug or diagnostic target would be incorrect based on available data[5].

Other names

dJ34B20.8H2AFUPHIST1H2APS3histone 1, H2a, pseudogene 3histone cluster 1 H2A pseudogene 3histone cluster 1, H2a, pseudogene 3