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H2B histone pseudogene 1 (H2BP1) is a human pseudogene derived from the gene for core histone H2B, a structural nuclear protein essential for the formation of nucleosomes and chromatin organization in eukaryotes. While functional histone H2B genes are required for chromatin structure and gene regulation, pseudogenes like H2BP1 are non-functional copies that do not encode active protein products and have no known biological or disease-related function. H2BP1 is located on chromosome 1 and is categorized as a pseudogene, distinguishing it from functional histone genes. There is no evidence that this pseudogene serves as a therapeutic target, nor are there established roles in disease, biomarker utility, or drug interactions[1][2][3].
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