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Target intelligence / Profile preview
H2B.K variant histone 1 (H2BK1)
- Target
- H2BK1
- Molecular classification
- Histone, Chromatin structural protein, Nucleosome core component, Histone variant
01
Overview
H2B.K variant histone 1 (H2BK1) is a member of the histone H2B family, serving as a core component of the nucleosome within chromatin. This protein plays a critical role in DNA packaging, regulation of transcription, DNA replication, repair, and chromosomal stability. H2BK1 is highly similar to the canonical H2B, with subtle sequence variations that may affect its interaction with DNA and other histones. In particular, the H2B type 1-K variant differs from others by a Ser124Ala substitution, possibly influencing nucleosome dynamics and accessibility. H2B.K accumulates in deep senescent cells with persistent DNA damage, suggesting a specialized role in chromatin regulation during senescence, and is associated with hematologic cancer. Although its physiological and disease roles are not fully understood, it is part of a complex set of post-translational histone modifications and structural chromatin regulation essential for nuclear function.
- Other names
- Histone H2B type 2-K1Histone H2B type 2-E1H2BK1H2BE1H2B.E variant histone 1Novel histone H2B-like proteinHIST1H2B1K
02
Mechanism of action
Not applicable. As a histone protein, it is not a classic drug target with well-defined mechanisms of drug action.
03
Biological functions
DNA packaging into chromatinStructural constituent of nucleosomeRegulation of DNA accessibilityTranscription regulationDNA repair (notably in senescent cells)
04
Disease associations
Cancer (associated, specifically hematologic cancer)Cellular senescencePotentially involved in genome instability
05
Safety considerations
None specific. No direct safety or therapeutic concern associated with targeting H2BK1, as it is not a drug target
06
Biomarkers
Senescence biomarker: H2B type 1-K enriches specifically in deeply senescent cells with persistent DNA damage and may serve as a molecular marker of cellular senescenceCancer: Expression changes might have biomarker potential in cancer, but no approved clinical use
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