H3 histone, family 3B pseudogene 1

H3 histone pseudogene 36 (H3P36) is a pseudogene, not a functional protein-coding gene or well-characterized therapeutic target. There is no evidence that this entity functions as a receptor, enzyme, or other drug target, nor is it involved in canonical histone functions. Most databases do not recognize "H3P36", "H3F3BP1", or any variant as a functional molecular entity. The canonical histone H3 family does not include this as a functional gene[4]. H3 histone pseudogene 36 (often listed as "H3P36", "H3F3BP1"), is classified as a pseudogene related to the H3 histone family. True H3 histones are core chromatin proteins subject to post-translational modification, such as methylation at lysine 36 (H3K36me), which is crucial for genomic stability, transcriptional regulation, and DNA repair[1][2][3]. However, pseudogenes like H3P36 do not encode functional proteins and lack any experimentally confirmed biological function or therapeutic relevance. The gene may be listed in genomic databases for annotation purposes, but not as a target associated with active chromatin regulation, diseases, or drug interaction. The canonical H3 histone proteins and their variants (e.g., H3.1, H3.2, H3.3) are well-established, but H3P36 does not appear among their recognized members[4]. There is potential confusion with functional H3 histone variants, such as H3.3 (H3F3B), but H3F3BP1 is a pseudogene and not identical to H3F3B. Information on H3K36 methylation is relevant only for true H3 proteins, not for this pseudogene[1][2][3]. Summary: H3 histone pseudogene 36 (H3P36, H3F3BP1) is not a functional gene, not a valid drug target, has no biological activity, and is likely included due to annotation or nomenclature confusion. The correct molecular entities involved in chromatin regulation (histone H3, H3K36 modifications) are unrelated to this pseudogene.

Other names

H3P36H3F3BP1p46H3 histone, family 3B (H3.3B) pseudogene 1H3 histone, family 3B pseudogene 1