H3 histone pseudogene 10 (H3P10)

H3 histone pseudogene 10 (H3P10) is classified as a pseudogene related to the histone H3 gene family[2]. Pseudogenes are non-functional segments of DNA that resemble functional genes but generally lack protein-coding ability and are not translated into functional proteins. Consequently, H3P10 does not represent a valid molecular target for therapeutics, diagnostics, or biomarker discovery. There is no evidence from current databases or the biomedical literature that H3P10 produces a functional RNA or protein product, or that it interacts with drugs, regulates cellular processes, or plays a direct role in disease. The alias "p16" is a source of confusion, as "p16" is also a widely used abbreviation for CDKN2A, a tumor suppressor protein and a well-established drug target with relevance to cancer—but H3P10 and CDKN2A/p16 are entirely unrelated at the molecular and functional level[2]. Critical note: - The name “H3 histone pseudogene 10” (H3P10) refers specifically to a human histone H3 pseudogene, not to a histone variant, modification, nor to the protein product “p16/INK4A,” which is a tumor suppressor involved in cell cycle regulation. - The symbol “p16” in this context is misleading—do not confuse it with the CDKN2A gene product p16/INK4A in cancer biology[2]. Summary decision: - H3P10 is not a relevant drug target. - This entry is likely to be incorrect/misleading if used in a therapeutic context due to confusion with “p16/INK4A” (CDKN2A). If you intended to inquire about the histone H3 family in chromatin regulation, canonical histone H3 proteins and their variants (such as H3.1, H3.2, H3.3) are functional, protein-coding, and have critical roles in gene regulation and chromatin structure[3]. If you intended the tumor suppressor p16/INK4A (CDKN2A), this is an entirely different, unrelated protein that is a bona fide drug target. All fields not applicable to non-target pseudogenes are set to null.

Other names

p16