H3 histone pseudogene 20 (H3P20)

H3 histone pseudogene 20 is a human pseudogene annotated in the NCBI Gene database. It is not transcribed into a protein and not known to encode a functional histone H3 variant[4]. Unlike canonical histone H3 genes that code for core histone proteins involved in DNA packaging and gene regulation[1][2], this pseudogene does not have an established biological role and is not considered a druggable or therapeutic target. The listing of "p58, H3P20" as its aliases appears to be nonstandard; "p58" is not a widely recognized synonym in the histone literature and may cause confusion with unrelated proteins or other gene products. Supporting details: - Pseudogenes are genetic sequences similar to known genes but typically lack the capacity to encode functional proteins due to mutations. - Histone H3 is indeed a major structural nucleosome component, with multiple coding genes and variants in the human genome[1][2], but pseudogenes such as H3P20 are nonfunctional remnants[4]. - H3P20 is not referenced in histone variant or drug target reviews; its function, if any, in cell or disease biology is not established[4]. Disambiguation: - There are functional histone H3 genes and variants (e.g., H3.1, H3.2, H3.3, H3.Y)[1][2][3][5], many of which are key regulators of chromatin function and gene expression. H3P20, however, is not among them; it is not a functional histone. - The "p58" alias seems to be incorrect or confusing, as it refers to various unrelated proteins in biomedical literature. Use of this synonym is discouraged in the context of histone biology. If you are searching for information on canonical histone H3 proteins or histone H3 variants, further clarification may be needed, as this entry only applies to the H3 histone pseudogene 20 (H3P20) and not functional histones.

Other names

p58H3P20