H3 histone pseudogene 47 (H3P47)

H3 histone pseudogene 47 (H3P47) is annotated as a pseudogene in the human genome, meaning it is a non-functional remnant of a gene that resembles the canonical histone H3 family but does not encode an active, functional protein[5]. Histone H3 genes encode proteins essential for DNA packaging and chromatin structure in eukaryotic cells, but pseudogenes like H3P47 are typically transcriptionally silent and do not contribute to histone pools or chromatin structure. "H3P47" has no established role as a therapeutic or pharmacological target, and the alias "p57" is used ambiguously—most commonly for the cyclin-dependent kinase inhibitor CDKN1C, not for this pseudogene. There are no known disease associations, biomarkers, or drugs targeting H3P47[5]. The biologically and clinically relevant H3 histone proteins and their variants are crucial for epigenetic regulation, but H3P47 does not participate in these processes[1][3][5].

Other names

H3 histone pseudogene 47H3P47p57 (ambiguous; also refers to CDKN1C)