H6 family homeobox 2 (HMX2)

H6 family homeobox 2 (HMX2) is a protein-coding gene that encodes a homeobox-containing transcription factor of the NKL homeobox family, playing a critical role in embryonic development, specifically in specifying neuronal cell types and ensuring proper development of the inner ear and hypothalamus. Variants involving HMX2 have been associated with inner ear malformations, vestibular dysfunction, hearing loss, and rare syndromic developmental diseases[1][7][8]. HMX2 is not generally considered a classical drug target (such as a receptor, enzyme, ion channel, or transporter), but rather a developmental transcription factor essential for regulation of gene expression during morphogenesis. No pharmacological modulators or drugs targeting HMX2 are known or reported in major clinical resources as of the current literature. No known biomarker or safety concerns have been specifically linked to direct targeting or modulation of HMX2[1][7][8].

Other names

Homeobox protein HMX2NKX5-2H6LNkx5-2homeobox protein H6 family member 2homeo box (H6 family) 2