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Haem Detoxification Pathway (HDP)
- Target
- HDP
- Molecular classification
- Metabolic pathway, Enzymatic pathway
01
Overview
The haem detoxification pathway is a critical biochemical process in the malaria parasite *Plasmodium falciparum*. It involves the conversion of toxic free haem, released during hemoglobin digestion, into an inert crystalline pigment called haemozoin. This pathway is essential for parasite survival and is the target of several antimalarial drugs.
- Other names
- Hemozoin formationMalaria pigment formationβ-hematin formation
02
Mechanism of action
Inhibition of haemozoin formation; binding of free haem; disruption of digestive vacuole function.
03
Biological functions
Haem detoxificationParasite survivalInhibition of oxidative damage
04
Disease associations
MalariaPlasmodium infection
05
Safety considerations
Drug resistanceTargeting host haem metabolism
06
Interacting drugs
Chloroquine
2 more in the full profile.
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