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Target intelligence / Profile preview
Influenza Virus Haemagglutinin Glycoprotein (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral protein, Fusion protein, Class I fusion protein
01
Overview
Haemagglutinin (HA) is a major glycoprotein found on the surface of influenza viruses. It is a homotrimeric protein that mediates viral attachment to host cells via sialic acid receptors and facilitates viral entry through membrane fusion. HA is a key target for neutralizing antibodies and antiviral drugs.
- Other names
- HaemagglutininHA1HA2
02
Mechanism of action
Inhibition of receptor binding; Blockage of membrane fusion
03
Biological functions
Receptor bindingMembrane fusionViral entryErythrocyte agglutination
04
Disease associations
InfectionInfluenza
05
Safety considerations
Antigenic drift due to mutations in the HA head domainNeed for updated seasonal vaccinesChallenges in developing universal influenza vaccines
06
Interacting drugs
IY7640
1 more in the full profile.
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