Haematoma resorption process

Haematoma resorption refers to the physiological process through which extravascular blood and its breakdown products are cleared from tissues following bleeding due to trauma, vascular injury, or surgery. This involves a tightly regulated interplay of immune cells (primarily macrophages and microglia), phagocytosis of red blood cells and degradation products via scavenger receptors (CD163, CD91, CD36), enzymatic breakdown of hemoglobin/heme (by heme oxygenases), and resolution of inflammatory and tissue repair responses. Efficient hematoma clearance is essential for neurological recovery after hemorrhagic brain injury and for successful tissue regeneration following bone fracture. Therapeutic approaches that accelerate hematoma resolution, such as immune cell modulation or administration of neurotrophic factors, are being explored to improve outcomes in conditions like intracerebral hemorrhage and chronic subdural hematoma.

Other names

hematoma resorptionhematoma clearancehematoma absorptionhematoma resolution

Modulation of immune cell activity (promoting scavenger receptor expression, erythrophagocytosis, anti-inflammatory mediators); Upregulation of pathways such as Nrf2-HO-1, Tie-2 (angiopoietin signaling); Enhanced phagocytosis/endocytosis via receptors like CD163, CD91, CD36