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Target intelligence / Profile preview
Haematopoietic Cell Kinase (HCK)
- Target
- HCK
- Molecular classification
- Enzyme, Protein Kinase, Non-receptor tyrosine kinase, Src family kinase
01
Overview
Haematopoietic cell kinase (HCK) is a non-receptor tyrosine kinase belonging to the Src family of kinases. It is primarily expressed in cells of the myeloid lineage (such as monocytes, macrophages, and neutrophils) and B-lymphocytes. HCK plays a central role in regulating immune cell signaling, proliferation, migration, adhesion, and inflammatory responses. Excessive activation or aberrant expression of HCK is linked to several leukemias as well as solid tumors such as breast and colon cancer. Selective inhibition of HCK is under investigation for cancer therapy due to its dual role: directly suppressing malignant cell growth/proliferation; indirectly reducing pro-tumorigenic changes within the microenvironment via effects on immune cells/macrophages.
02
Mechanism of action
Inhibition of HCK kinase activity, blocking downstream signaling pathways (PI3K/AKT/MAPK/ERK/STAT5/NLRP3 inflammasome)
03
Biological functions
Immune regulationCytokine secretionCell proliferationCell migrationCell invasionApoptosisCell adhesionSignal transductionInflammation regulation
04
Disease associations
CancerLeukemiaBreast cancerColon cancerInflammationDrug resistance
05
Safety considerations
Potential for off-target effects with less selective Src-family kinase inhibitorsUnclear long-term effects of HCK inhibition on normal immune function
06
Interacting drugs
Src-family kinase inhibitors
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