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Target intelligence / Profile preview
Haematopoietic Prostaglandin D Synthase (HPGDS)
- Target
- HPGDS
- Molecular classification
- Enzyme, Sigma-class Glutathione S-transferase
01
Overview
Haematopoietic prostaglandin D synthase is a key cytosolic enzyme responsible for producing PGD₂ from PGH₂ via a glutathione-dependent mechanism. It plays central roles both as an effector molecule generator during immune responses—influencing leukocyte migration/cytokine production—and as a potential therapeutic target for diseases involving dysregulated inflammation such as asthma or allergy. Its unique structure among GSTs makes it distinct from other prostaglandin synthases found primarily within the CNS/lipocalins family.
- Other names
- Hematopoietic Prostaglandin D SynthaseHematopoietic PGD SynthaseH-PGDS
02
Mechanism of action
Inhibition of PGD2 synthesis
03
Biological functions
Prostaglandin biosynthesisRegulation of inflammation onset and resolutionLeukocyte traffickingCytokine production modulationSleep regulationBody temperature regulationVasodilationPlatelet aggregation inhibitionBronchoconstriction
04
Disease associations
InflammationAsthmaAllergy
05
Safety considerations
Dual pro-inflammatory or anti-inflammatory roles depending on context
06
Interacting drugs
HQL-79
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