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Target intelligence / Profile preview
Haeme-mediated Free Radical Generation (N/A)
- Target
- N/A
- Molecular classification
- Biochemical Pathway, Redox process, Drug Target
01
Overview
Haeme-mediated free radical generation is a critical biochemical process in Plasmodium species. It involves the release of free heme during hemoglobin digestion, leading to ROS production via Fenton chemistry. This process influences pathogenesis and serves as a target for antimalarial therapies. Plasmodium converts toxic free heme into hemozoin to mitigate oxidative stress. Many antimalarial drugs, such as artemisinin and chloroquine, exploit this pathway to induce parasite death. Excessive free heme released during hemolysis can also trigger inflammation and thrombosis in the host.
- Other names
- Heme-mediated Free Radical GenerationHeme detoxification pathwayROS production in PlasmodiumHemozoin formation pathway
02
Mechanism of action
Artemisinin derivatives interact with ferrous iron in heme to generate cytotoxic free radicals. Chloroquine inhibits the biocrystallization of hemozoin from free heme.
03
Biological functions
Hemoglobin digestionReactive oxygen species (ROS) generationHemozoin formationOxidative stressParasite survivalDrug mechanism of action
04
Disease associations
Malaria pathogenesisInflammationThrombosis
05
Safety considerations
Drug resistance developmentHost cell damage due to ROSInflammatory response due to circulating heme
06
Interacting drugs
Artemisinin
1 more in the full profile.
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