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Target intelligence / Profile preview
Haemophilus influenzae Capsular Polysaccharide (None)
- Target
- None
- Molecular classification
- Polysaccharide, Capsular Polysaccharide
01
Overview
The capsular polysaccharide of Haemophilus influenzae, particularly type b (Hib), is a high-molecular-weight polymer that forms the outermost structure of encapsulated H. influenzae bacteria. This capsule is a critical virulence factor, enabling the bacterium to evade host immune responses and cause invasive diseases such as meningitis and pneumonia, especially in children. It is composed of repeating units of polyribosyl-ribitol-phosphate (PRP). Antibodies against it confer protection against Hib disease, making it a target for vaccination strategies.
- Other names
- Hib capsular polysaccharidePRP (polyribosyl-ribitol-phosphate)
02
Mechanism of action
Antibodies against PRP confer protection against Hib disease. Hib conjugate vaccines induce robust immune responses.
03
Biological functions
Evasion of host immune responseProtection from phagocytosisProtection from complement-mediated killingBacterial virulence
04
Disease associations
Meningitis (bacterial)Pneumonia (bacterial)Invasive Haemophilus influenzae type b disease
05
Interacting drugs
Hib conjugate vaccines
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