Target intelligence / Profile preview

Haemophilus influenzae Protein D

Molecular classification: Lipoprotein, Enzyme

Overview

Protein D is a highly conserved, 42 kDa surface-exposed lipoprotein found in all strains of Haemophilus influenzae. It exhibits glycerophosphodiesterase activity and binds immunoglobulin D, playing roles in virulence and immune modulation. It is a target for direct vaccines against nontypeable H. influenzae infections and also serves as a carrier protein for conjugate vaccines like Synflorix™.

Mechanism of action

Hydrolyzes glycerophosphodiesters, modulating host-pathogen interactions and impairing ciliary function. Acts as a carrier protein to enhance the immunogenicity of conjugated antigens.

Biological functions

Glycerophosphodiesterase activityIgD bindingImmune modulationAdhesion

Disease associations

InfectionOtitis mediaRespiratory tract infections

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