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Target intelligence / Profile preview
Haemophilus influenzae type b capsular polysaccharide–tetanus toxoid conjugate (PRP-T)
- Target
- PRP-T
- Molecular classification
- Biotech/biologic, Inactivated/conjugate/toxoid vaccine
01
Overview
The Haemophilus influenzae type b (Hib) capsular polysaccharide–tetanus toxoid conjugate is a vaccine antigen used to prevent invasive diseases caused by the bacterium *Haemophilus influenzae* type b. It consists of the PRP capsular polysaccharide from Hib covalently linked to tetanus toxoid protein. This conjugation allows for a T-cell dependent immune response, leading to robust antibody production and immunological memory, thus protecting against severe childhood infections caused by Hib.
- Other names
- Haemophilus influenzae type B strain 1482 capsular polysaccharide–tetanus toxoid conjugate vaccineHib conjugate vaccine (tetanus toxoid carrier)ActHIBHiberixMenhibrix
02
Mechanism of action
Induces anti-Hib antibodies via T-cell dependent pathway
03
Biological functions
Induction of humoral immune responseB cell activationAntibody productionImmunological memory formationPrevention of bacterial infection
04
Disease associations
InfectionHaemophilus influenzae type b infectionsMeningitisEpiglottitisPneumoniaPericarditisSeptic arthritis
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