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Target intelligence / Profile preview
Haemophilus influenzae type b capsular polysaccharide (polyribosylribitol phosphate) (PRP)
- Target
- PRP
- Molecular classification
- Polysaccharide, Capsular Polysaccharide
01
Overview
Haemophilus influenzae type b capsular polysaccharide, also known as polyribosylribitol phosphate (PRP), is a linear polymer composed of repeating units of ribose and ribitol-5-phosphate. This molecule forms the capsule that surrounds Hib bacteria and is a critical virulence factor, enabling the bacterium to evade host immune responses and cause invasive diseases—especially in young children. It is the main antigenic component targeted by all licensed Hib conjugate vaccines.
- Other names
- Polyribosylribitol phosphateHaemophilus influenzae type b capsular polysaccharide
02
Mechanism of action
Conjugation to carrier proteins to elicit T-cell dependent immune responses and antibody production against PRP
03
Biological functions
Evasion of host immune responsesInhibition of serum bactericidal activityInhibition of complement-mediated phagocytosisVirulence factor
04
Disease associations
MeningitisSepticemiaEpiglottitisPneumoniaSeptic arthritisHaemophilus influenzae type b infection
05
Safety considerations
Potential for vaccine failure in immunocompromised individualsRare adverse reactions to Hib conjugate vaccines
06
Interacting drugs
Hib conjugate vaccines (PRP-D, HbOC, PRP-OMP, PRP-T)
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