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Target intelligence / Profile preview
Haemophilus influenzae type b capsular polysaccharide antigen (PRP)
- Target
- PRP
- Molecular classification
- Polysaccharide, Capsular Polysaccharide Antigen
01
Overview
The Haemophilus influenzae type b (Hib) capsular polysaccharide antigen (PRP) is a high-molecular-weight polymer that forms the capsule surrounding Hib bacteria. This capsule protects Hib from host immune defenses and is the primary target for protective immune responses elicited by conjugate vaccines, which have dramatically reduced the incidence of invasive Hib disease.
- Other names
- Hib capsular polysaccharidePolyribosyl-ribitol-phosphate
02
Mechanism of action
Induction of anti-PRP antibodies that neutralize and clear the bacteria.
03
Biological functions
Antiphagocytic shieldVirulence factorElicits protective immune response
04
Disease associations
InfectionMeningitisSepsis
05
Interacting drugs
Hib vaccines (Conjugate vaccines)
06
Biomarkers
Anti-PRP antibody levels (≥1.0 mcg/mL predicts protection)
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