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Haemophilus influenzae type b capsular polysaccharide conjugated to tetanus protein
- Molecular classification
- Polysaccharide, Protein conjugate, Vaccine antigen
01
Overview
The capsular polysaccharide of *Haemophilus influenzae* type b (Hib), specifically polyribosyl-ribitol-phosphate (PRP), covalently conjugated to tetanus toxoid protein. This conjugate vaccine stimulates the production of anti-PRP antibodies, providing protection against invasive Hib diseases. The tetanus toxoid conjugation enhances immunogenicity through a T-cell dependent immune response.
- Other names
- Hib conjugate vaccinePRP-T vaccineHiberixActHIB
02
Mechanism of action
Induces production of anti-PRP antibodies that confer protection against *Haemophilus influenzae* type b infection. Conjugation to tetanus toxoid enhances immunogenicity, particularly in infants, by eliciting a T-cell dependent immune response.
03
Biological functions
Induction of humoral immunityAntibody productionT-cell dependent immune response
04
Disease associations
Prevention of Haemophilus influenzae type b invasive diseasePrevention of Meningitis (Hib)Prevention of Sepsis (Hib)Prevention of Pneumonia (Hib)Prevention of Epiglottitis (Hib)
05
Safety considerations
Injection site painFeverRare allergic reactions
06
Biomarkers
Anti-PRP antibody concentration (≥0.15 mcg/mL considered protective)
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