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Target intelligence / Profile preview
Haemophilus influenzae type b capsular polysaccharide conjugated to tetanus toxoid (PRP-TT)
- Target
- PRP-TT
- Molecular classification
- Vaccine, Conjugate Vaccine, Polysaccharide-protein conjugate
01
Overview
Haemophilus influenzae type b capsular polysaccharide conjugated to tetanus toxoid (PRP-TT) is a glycoconjugate used in highly effective pediatric vaccines against Hib disease. It consists of purified bacterial capsule sugar chains covalently attached to detoxified tetanus protein carrier—enabling robust antibody production even in very young children who would otherwise respond poorly if given only plain bacterial sugars as antigens.
- Other names
- Haemophilus B Conjugate Vaccine (PRP-T)Haemophilus influenzae type B strain 1482 capsular polysaccharide-tetanus toxoid conjugateActHIBHiberix
02
Mechanism of action
Stimulates the immune system to produce antibodies against the PRP capsule of H. influenzae type b. Conjugation to tetanus toxoid enhances immunogenicity and induces a T-cell dependent response, leading to stronger and longer-lasting immunity.
03
Biological functions
Induction of humoral immunityB cell activationT cell activationAntibody productionImmunological memory
04
Disease associations
Prevention of Haemophilus influenzae type b infectionsPrevention of meningitisPrevention of sepsis
05
Safety considerations
Mild local reactionsPotential allergic reactions
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