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Target intelligence / Profile preview
Haemophilus influenzae type b Capsular Polysaccharide Conjugated to Tetanus Toxoid Carrier Protein (Hib-TT)
- Target
- Hib-TT
- Molecular classification
- Polysaccharide-protein conjugate, Vaccine antigen
01
Overview
Haemophilus influenzae type b (Hib) capsular polysaccharide conjugated to tetanus toxoid is the active component in Hib conjugate vaccines. The vaccine induces immunity by stimulating the production of antibodies against the PRP component. Conjugation to tetanus toxoid allows infants and young children to mount an effective immune response through T-cell help, providing protection against invasive Hib diseases.
- Other names
- Hib conjugate vaccinePRP-T vaccinePolyribosyl-ribitol-phosphate conjugated to tetanus toxoid
02
Mechanism of action
Induces anti-polyribosyl-ribitol-phosphate (anti-PRP) antibodies via T-cell dependent immune response by conjugating PRP to tetanus toxoid, enhancing antigen presentation and B cell activation.
03
Biological functions
Antigen presentationImmune response inductionB cell activationAntibody production
04
Disease associations
InfectionHaemophilus influenzae type b infectionMeningitisSepsisPneumoniaEpiglottitis
05
Safety considerations
Injection site reactions (pain, swelling, redness)FeverRare allergic reactions
06
Interacting drugs
ActHIB
4 more in the full profile.
07
Biomarkers
Anti-PRP antibody levels
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