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Target intelligence / Profile preview
Haemophilus influenzae type b Capsular Polysaccharide PRP Conjugated to Tetanus Toxoid Protein Carrier (PRP-T)
- Target
- PRP-T
- Molecular classification
- Polysaccharide, Toxoid, Conjugate Vaccine
01
Overview
Haemophilus influenzae type b (Hib) capsular polysaccharide, known as polyribosyl-ribitol-phosphate (PRP), is conjugated to tetanus toxoid (TT) to enhance its immunogenicity, particularly in infants. The conjugation process transforms the immune response from T-cell independent to T-cell dependent, resulting in improved antibody production. This conjugate vaccine is used for prevention of invasive diseases caused by H. influenzae type b such as meningitis and sepsis. Tetanus toxoid serves as an effective carrier protein due to its ability to stimulate T-cell responses.
- Other names
- Haemophilus influenzae type B strain 1482 capsular polysaccharide–inactivated tetanus toxoid conjugate vaccinePRP-T conjugate vaccine
02
Mechanism of action
Stimulates the production of anti-PRP antibodies by converting the immune response from T-cell independent to T-cell dependent through conjugation to tetanus toxoid.
03
Biological functions
Induction of humoral immunityAntibody productionT-cell dependent immune response
04
Disease associations
Prevention of Haemophilus influenzae type b invasive diseasesPrevention of meningitisPrevention of sepsis
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