Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Haemophilus influenzae type b polyribosyl-ribitol-phosphate-tetanus toxoid conjugate (PRP-T)
- Target
- PRP-T
- Molecular classification
- Vaccine, Inactivated, Toxoid, Conjugate
01
Overview
The PRP-T is a conjugate vaccine component designed to prevent infections caused by *Haemophilus influenzae* type b (Hib), a Gram-negative bacterium responsible for severe diseases such as meningitis, epiglottitis, pneumonia, septic arthritis, and pericarditis in young children. The vaccine consists of the Hib capsular polysaccharide—polyribosyl-ribitol-phosphate (PRP)—covalently linked to tetanus toxoid protein. This conjugation enhances immunogenicity by enabling T-cell dependent immune responses in infants and young children who otherwise respond poorly to plain polysaccharide antigens.
- Other names
- Haemophilus influenzae type B strain 1482 capsular polysaccharide–inactivated tetanus toxoid conjugate vaccineHaemophilus b conjugate (PRP-T) vaccineActHIB®Hiberix®
02
Mechanism of action
Induces anti-Hib immunity via T-dependent response
03
Biological functions
Induction of anti-Hib immunityB-cell activationT-cell activationImmunological memory
04
Disease associations
InfectionPrevention of Haemophilus influenzae type b invasive diseases
05
Safety considerations
Local reactions (redness/swelling)Fever (>102°F)IrritabilityRare seizures
Beyond the preview
Go deeper on Haemophilus influenzae type b polyribosyl-ribitol-phosphate-tetanus toxoid conjugate (PRP-T).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Haemophilus influenzae type b polyribosyl-ribitol-phosphate-tetanus toxoid conjugate (PRP-T).