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Target intelligence / Profile preview
Haemophilus influenzae type b Polyribosylribitol Phosphate (PRP)
- Target
- PRP
- Molecular classification
- Polysaccharide, Capsular polysaccharide, Antigen
01
Overview
Polyribosylribitol phosphate (PRP) is the capsular polysaccharide antigen specific to Haemophilus influenzae type b (Hib). It is a high-molecular-weight polymer that forms the outer capsule of Hib bacteria, serving as a major virulence factor and the primary target for protective immune responses and vaccine development. PRP consists of repeating units composed of D-ribose, ribitol, and phosphate. It protects Hib from host immune defenses by inhibiting complement-mediated phagocytosis and shielding bacterial surface antigens. Antibody responses against PRP are critical for clearance of Hib bacteria. PRP is used as a conjugate with carrier proteins in vaccines to elicit robust T-cell-dependent immunity.
- Other names
- Hib PRPPolyribosylribitol PhosphateHaemophilus influenzae type b capsular polysaccharide
02
Mechanism of action
Conjugate vaccines elicit T-cell-dependent immunity against PRP, leading to opsonization, complement activation, and bacterial clearance.
03
Biological functions
Immune evasionVirulence factorAntigenComplement inhibitionProtection against phagocytosis
04
Disease associations
InfectionHaemophilus influenzae type b infection
05
Interacting drugs
PRP-D (Diphtheria Toxoid conjugate)
3 more in the full profile.
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