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Target intelligence / Profile preview
Haemophilus influenzae type b polysaccharide–tetanus toxoid conjugate (PRP-T)
- Target
- PRP-T
- Molecular classification
- Bacterial capsular polysaccharide-protein conjugate, Vaccine antigen
01
Overview
The Haemophilus influenzae type b polysaccharide–tetanus toxoid conjugate (PRP-T) is a vaccine antigen used for active immunization against invasive diseases caused by Haemophilus influenzae type b (Hib). It consists of the capsular polysaccharide from H. influenzae type b covalently linked to tetanus toxoid protein, inducing a T-cell dependent IgG antibody response against the Hib capsular polysaccharide. This leads to the production of anti-capsular PRP antibodies with bactericidal activity against Hib, providing protection against invasive disease.
- Other names
- Hib vaccineActHIBHiberix
02
Mechanism of action
Induces T-dependent IgG response targeting Hib capsule via presentation on tetanus toxoid carrier
03
Biological functions
Induction of antibody responseActive immunization
04
Disease associations
InfectionHaemophilus influenzae type b invasive disease
05
Safety considerations
Mild pain at injection siteLow-grade feverRare severe allergic reactions
06
Interacting drugs
None (vaccine itself is the interacting agent)
07
Biomarkers
Anti-Hib antibody titers (>1.0 mcg/mL)
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