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Haemophilus influenzae type b polysaccharide capsule (None)

Target: None
Molecular classification: Polysaccharide, Capsular polysaccharide

Overview

The Haemophilus influenzae type b (Hib) polysaccharide capsule is a critical virulence factor that enables the bacterium to evade host immune responses and cause invasive diseases. It is composed of polyribosyl-ribitol-phosphate (PRP). The PRP component forms the basis for current conjugate vaccines against Hib, which induce strong T-cell dependent immune responses. The capsule protects Hib from phagocytosis and complement-mediated killing, making it the main determinant for virulence.

Other names: Hib capsulePRP capsulePolyribosyl-ribitol-phosphate capsule

Mechanism of action

Vaccines induce antibody production against PRP, leading to opsonization and complement-mediated killing of Hib.

Biological functions

Immune evasionVirulence factorAntigen

Disease associations

InfectionMeningitisSepsisEpiglottitisSeptic arthritis

Safety considerations

Vaccine site reactionsRare allergic reactions

Interacting drugs

Hib conjugate vaccines (e.g., PRP-T, PRP-OMP, PRP-HbOC)

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