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Haemophilus influenzae type b Polysaccharide Capsule Antigen
- Molecular classification
- Polysaccharide, Capsular Antigen
01
Overview
The Haemophilus influenzae type b (Hib) polysaccharide capsule antigen is a surface-expressed polymer of polyribosyl-ribitol-phosphate (PRP). It is the principal virulence factor enabling the bacterium to evade host immune responses. It is the target of Hib conjugate vaccines, which induce protective immunity by eliciting T-cell dependent responses.
02
Mechanism of action
Antibody-mediated neutralization and opsonization following vaccination.
03
Biological functions
Immune evasionVirulence factorAntigen presentation (via conjugate vaccines)
04
Disease associations
InfectionMeningitisPneumoniaSepticemia
05
Safety considerations
Limited immunogenicity in infants without conjugation
06
Interacting drugs
Hib conjugate vaccines
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