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Haemophilus influenzae type b Polysaccharide Capsule Conjugated to Tetanus Protein Carrier (PRP-T)

Target: PRP-T
Molecular classification: Polysaccharide, Conjugate Vaccine, Antigen

Overview

The Haemophilus influenzae type b (Hib) polysaccharide capsule conjugated to tetanus protein carrier is a conjugate vaccine designed to elicit a strong, T-cell dependent immune response against the Hib capsular polysaccharide (PRP). The PRP component is covalently linked to tetanus toxoid, which enhances immunogenicity, particularly in infants. This conjugate vaccine promotes antibody production, immunological memory, and effective protection against invasive Hib diseases.

Other names: Hib conjugate vaccinePRP-T vaccinePolyribosyl-ribitol-phosphate tetanus toxoid conjugate vaccine

Mechanism of action

Induces a T-cell dependent immune response by presenting the bacterial polysaccharide antigen (PRP) and the tetanus toxoid carrier protein to B cells, leading to robust antibody production and long-term immunity.

Biological functions

Immune response inductionAntibody productionImmunological memory formationPrevention of bacterial infection

Disease associations

InfectionHaemophilus influenzae type b invasive diseaseMeningitisSepsisEpiglottitis

Safety considerations

FeverLoss of appetiteRedness or swelling at injection siteRare severe allergic reactions

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